反应详情

1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 0.84 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (1 equiv.) and potassium carbonate (2 equiv.) were heated to 50° C. over night in EtOH (5 mL). The crude product was extracted into DCM and solvent was evaporated. The crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes) followed by prepHPLC to afford the titled compound.

1. extractionThe crude product was extracted into DCM and solvent
2. customwas evaporated
3. customThe crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes)