反应详情

At 0° C., the compound 2-fluoro-4-{4-[2-(phenoxymethyl)-1H-imidazol-4-yl]phenoxy}aniline (1.5 g, 4 mmol) and triethylamine (0.63 ml, 4.52 mmol) are solubilized in 10 ml of dichloromethane. A mixture containing sulfonyl isocyanate chloride (0.623 g, 4.40 mmol) and tert-butanol (0.325 g, 4.40 mmol) in 10 ml of dichloromethane is added to this solution at 0° C. The reaction medium is returned to ambient temperature then stirred for two hours. After evaporation of the solvent, the solid obtained is purified on a silica column (eluent: dichloromethane-methanol: 95-5). After washing in dichloromethane then filtration, a yellow-coloured powder is obtained with a yield of 75%.

1. customAt 0° C.
2. additionis added to this solution at 0° C
3. customis returned to ambient temperature
4. customAfter evaporation of the solvent
5. customthe solid obtained
6. customis purified on a silica column (eluent: dichloromethane-methanol: 95-5)
7. washAfter washing in dichloromethane
8. filtrationfiltration
9. customa yellow-coloured powder is obtained with a yield of 75%