Hydrochloric Acid → HCID 68821511, compound

HRID 1930800Notes

Reaction equation

HRID 1930800 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:17].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[CH2:9][NH:8][CH2:16]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57753283HCID 57753283, compound

Product 1

HCID 68821511HCID 68821511, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

To a stirred suspension of 0.12 mmol 5-chloro-6-pyrrolidin-1-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester in 1 ml dioxane was added 1.86 mmol hydrogen chloride solution (4 M in dioxane) and the mixture was stirred at 90° C. for 2 h. The reaction mixture was then concentrated in vacuo to yield the title compound as a brown solid which was used in the next step without further purification. MS (m/e): 325.2 ({37Cl}M+H+, 35%), 323.2 ({35Cl}M+H+, 100%).

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-ac5949a81fe7468aadffb7a31d55933b
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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