Hydrochloric Acid → 5-Chloro-6-methyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 1930802Notes

Reaction equation

HRID 1930802 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH3:18])=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[ClH:17].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[CH3:18])[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577533615-Chloro-6-methyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688257895-Chloro-6-methyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3 (e) from 5-chloro-6-methyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and HCl. Grey solid. MS (m/e): 170.1 ({37Cl}M+H+, 35%), 168.3 ({35Cl}M+H+, 100%).

Sources & evidence

ORD record
ord-2978bc47fabc4700b99314e51d7bb651
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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