Hydrochloric Acid → 5-Chloro-6-methoxy-2,3-dihydro-1H-isoindole hydrochloride

HRID 1930806Notes

Reaction equation

HRID 1930806 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[ClH:17].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:18][CH3:19])[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577536115-Chloro-6-methoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688230895-Chloro-6-methoxy-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3 (e) from 5-chloro-6-methoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and HCl. Off-white solid. MS (m/e): 186.1 ({37Cl}M+H+, 30%), 184.1 ({35Cl}M+H+, 100%).

Sources & evidence

ORD record
ord-6fee5e11232f46059256243e79d6a0a4
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

Loading…