Trifluoroacetic acid → Isoindoline-4-carbonitrile

HRID 1930811Notes

Reaction equation

HRID 1930811 reaction equation
C([N:20]1[CH2:28][C:27]2[C:26]([C:29]#[N:30])=[CH:25][CH:24]=[CH:23][C:22]=2[CH2:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.FC(F)(F)C(O)=O>>[CH2:21]1[C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([C:29]#[N:30])[C:27]=2[CH2:28][NH:20]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577534312-trityl-2,3-dihydro-1H-isoindole-4-carbonitrile

Product 1

HCID 50999317Isoindoline-4-carbonitrile

Procedure

Prepared in analogy to Example A2 (c) from 2-trityl-2,3-dihydro-1H-isoindole-4-carbonitrile and trifluoroacetic acid. Light brown solid.

Sources & evidence

ORD record
ord-bcc258d460584a96bff7b0723163a732
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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