Hydrochloric Acid → 5-Ethylsulfanyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 1930815Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([S:17][CH2:18][CH3:19])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[CH2:18]([S:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2)[CH3:19]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 577536005-Ethylsulfanyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688216235-Ethylsulfanyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3 (e) from 5-Ethylsulfanyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and HCl. Light Brown solid. MS (m/e): 216.3 ([M+H+, 100%).

Sources & evidence

ORD record: ord-d57664fa6ffc4b7489eb8973e46ec553
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188139B2

Reaction notes

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