Trifluoroacetic acid → 5-Chloro-6-fluoro-2,3-dihydro-1H-isoindole

HRID 1930817Notes

Reaction equation

HRID 1930817 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[CH2:7][N:6](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:5]2.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[CH2:7][NH:6][CH2:5]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577533905-chloro-6-fluoro-2-trityl-2,3-dihydro-1H-isoindole

Product 1

HCID 577533575-Chloro-6-fluoro-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A2 (c) from 5-chloro-6-fluoro-2-trityl-2,3-dihydro-1H-isoindole and trifluoroacetic acid. Light brown solid.

Sources & evidence

ORD record
ord-cacacb0acde247d08b4e1e58424dd0b3
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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