Trifluoroacetic acid → HCID 86607007, compound

HRID 1930845Notes

Reaction equation

HRID 1930845 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[CH:14]=[N:13][C:12]([C:17]([F:20])([F:19])[F:18])=[N:11][C:10]=2[CH2:9]1)=O)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[F:20][C:17]([F:18])([F:19])[C:12]1[N:13]=[CH:14][C:15]2[CH2:16][NH:8][CH2:9][C:10]=2[N:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 52988153tert-Butyl 2-(trifluoromethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

Product 1

HCID 86607007HCID 86607007, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.4 mmol of 2-Trifluoromethyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester was dissolved in a mixture of 20 ml dichloromethane and 3 g trifluoroacetic acid. The mixture was hold at 45° C. for 3 hours and concentrated to give the title compound as a waxy solid. Yield=100%. MS (m/e): 190.3 ([M+H]+, 100%).

Workup

  1. customat 45° C.
  2. customfor 3 hours
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-fc71068022104f259004b365583fa2b1
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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