Hydrochloric Acid → 5-Ethylsulfanyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 1930851Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:20]([F:23])([F:22])[F:21])=[C:13]([S:17][CH2:18][CH3:19])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>>[ClH:24].[CH2:18]([S:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[C:20]([F:23])([F:21])[F:22])[CH2:9][NH:8][CH2:16]2)[CH3:19]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 57753436HCID 57753436, compound

Product 1

HCID 688216305-Ethylsulfanyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-ethylsulfanyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Yellow solid. MS (m/e): 284.3 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-824efb1dd7d040288c53bdf6f019865d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188139B2

Reaction notes

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