Methanol → HCID 86607008, compound

HRID 1930854Notes

Reaction equation

HRID 1930854 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[CH2:7][N:6](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:5]2.CO.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>C(Cl)(Cl)Cl>[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39].[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([F:13])([F:12])[F:14])[CH2:7][NH:6][CH2:5]2

Participants

5

Reactant 3

HCID 887MethanolHCID 6422Trifluoroacetic acidHCID 57753224HCID 57753224, compound

Product 1

HCID 86607008HCID 86607008, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixture of 0.33 mmol 5-fluoro-6-trifluoromethyl-2-trityl-2,3-dihydro-1H-isoindole in 1.5 methanol and 1.5 ml chloroform at 0° C. was added dropwise 1.63 mmol trifluoroacetic acid and the mixture was then stirred at RT for 3 h before being concentrated in vacuo to afford the title compound as a yellow solid (100% yield). EI-MS (m/e): 206.1 ([M+H]+, 100%).

Workup

  1. concentrationbefore being concentrated in vacuo

Sources & evidence

ORD record
ord-641793d008d84c94b88bc1cf7fffecc3
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

Loading…