Hydrochloric Acid → HCID 68822803, compound

HRID 1930866Notes

Reaction equation

HRID 1930866 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:22][CH2:21][C:20]([F:24])([F:23])[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:25]>>[ClH:25].[F:24][C:20]1([F:23])[CH2:21][CH2:22][N:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57753513HCID 57753513, compound

Product 1

HCID 68822803HCID 68822803, compound

Procedure

Prepared in analogy to Example A3(e) from 5-(4,4-difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Light yellow solid. MS (m/e): 239.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-e3ac3db9019749daa26cde52ed28f1db
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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