Stannane, tributyl(1-ethoxyethenyl)- → 1-(6-Trifluoromethyl-2,3-dihydro-1H-isoindol-5-yl)-ethanone

HRID 1930876Notes

Reaction equation

HRID 1930876 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18]([F:21])([F:20])[F:19])=[C:13](I)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[CH2:22]([O:24]C([Sn](CCCC)(CCCC)CCCC)=C)[CH3:23]>>[F:21][C:18]([F:19])([F:20])[C:12]1[CH:11]=[C:10]2[C:15]([CH2:16][NH:8][CH2:9]2)=[CH:14][C:13]=1[C:22](=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 57753490HCID 57753490, compound

Product 1

HCID 577532811-(6-Trifluoromethyl-2,3-dihydro-1H-isoindol-5-yl)-ethanone

Procedure

Prepared in analogy to Example A47 from 5-iodo-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A35(d)) and 1-ethoxyvinyltributylstannane. White solid. MS (m/e): 230.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-6da8c10a1ed04f42b34439988812fc48
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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