3,3-Difluoropiperidine hydrochloride → 5-(3,3-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 1930885Notes

Reaction equation

HRID 1930885 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[F:19][C:20]1([F:26])[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:22]3[CH2:23][CH2:24][CH2:25][C:20]([F:26])([F:19])[CH2:21]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27583493,3-Difluoropiperidine hydrochlorideHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577536445-(3,3-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 3,3-difluoropiperidine hydrochloride. Pink solid. MS (m/e): 339.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-9ebfcfdf56574eb0852baed7dc3bee02
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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