HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Difluoropiperidine hydrochloride → 5-(3,3-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Difluoropiperidine hydrochloride | HCID 2758349 | — |
| Reactant | tert-Butyl 5-iodoisoindoline-2-carboxylate | HCID 57753580 | — |
| Product | 5-(3,3-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester | HCID 57753644 | — |
Reaction Steps
Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 3,3-difluoropiperidine hydrochloride. Pink solid. MS (m/e): 339.1 ([M+H]+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9ebfcfdf56574eb0852baed7dc3bee02 |
| Source note | uspto-grants-2012_05 |