Hydrochloric Acid → HCID 68822060, compound

HRID 1930888Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:22][CH2:21][C:20]([OH:29])([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:30]>>[ClH:30].[CH2:9]1[C:10]2[C:15](=[CH:14][C:13]([N:17]3[CH2:18][CH2:19][C:20]([C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)([OH:29])[CH2:21][CH2:22]3)=[CH:12][CH:11]=2)[CH2:16][NH:8]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 57753235HCID 57753235, compound

Product 1

HCID 68822060HCID 68822060, compound

Procedure

Prepared in analogy to Example A3(e) from 5-(4-hydroxy-4-phenyl-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Off-white solid. MS (m/e): 295.4 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-1dea67d92ebb4ed5ba9f9c5e72bd8811
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188139B2

Reaction notes

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