3-Oxa-8-azabicyclo(3.2.1)octane hydrochloride → 5-(3-Oxa-8-aza-bicyclo[3.2.1]oct-8-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 1930901Notes

Reaction equation

HRID 1930901 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH:19]12[NH:26][CH:23]([CH2:24][CH2:25]1)[CH2:22][O:21][CH2:20]2>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:26]3[CH:19]4[CH2:25][CH2:24][CH:23]3[CH2:22][O:21][CH2:20]4)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 534011293-Oxa-8-azabicyclo(3.2.1)octane hydrochlorideHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577534235-(3-Oxa-8-aza-bicyclo[3.2.1]oct-8-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 3-oxa-8-azabicyclo[3.2.1]octane hydrochloride. Yellow oil. MS (m/e): 331.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-392e8c89d1104dba8f1f76c7ec83ed6b
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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