HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxa-8-azabicyclo(3.2.1)octane hydrochloride → 5-(3-Oxa-8-aza-bicyclo[3.2.1]oct-8-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxa-8-azabicyclo(3.2.1)octane hydrochloride | HCID 53401129 | — |
| Reactant | tert-Butyl 5-iodoisoindoline-2-carboxylate | HCID 57753580 | — |
| Product | 5-(3-Oxa-8-aza-bicyclo[3.2.1]oct-8-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester | HCID 57753423 | — |
Reaction Steps
Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 3-oxa-8-azabicyclo[3.2.1]octane hydrochloride. Yellow oil. MS (m/e): 331.4 ([M+H]+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188139B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-392e8c89d1104dba8f1f76c7ec83ed6b |
| Source note | uspto-grants-2012_05 |