Trifluoroacetic acid → 5-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetate

HRID 1930908Notes

Reaction equation

HRID 1930908 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[C:13]([CH:17]3[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH:17]1([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][C:12]=2[CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH2:9][NH:8][CH2:16]3)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577533055-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

Product 1

HCID 688258565-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetate

Procedure

Prepared in analogy to Example A2(c) from 5-cyclopropyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown solid. MS (m/e): 244.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-4d57c1e15f504caa9cab4711ab779305
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

Loading…