Trifluoroacetic acid → HCID 68823029, compound

HRID 1930955Notes

Reaction equation

HRID 1930955 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:17][CH:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[O:21]1[CH2:22][CH2:23][CH:18]([O:17][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57753714HCID 57753714, compound

Product 1

HCID 68823029HCID 68823029, compound

Procedure

Prepared in analogy to Example A2(c) from 5-(tetrahydro-pyran-4-yloxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. MS (m/e): 220.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-3bd6f1a13150463eb577623385dd80e5
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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