Trifluoroacetic acid → 5-(3,3,3-Trifluoro-propoxy)-2,3-dihydro-1H-isoindole trifluoroacetate

HRID 1930962Notes

Reaction equation

HRID 1930962 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:17][CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[F:23][C:20]([F:21])([F:22])[CH2:19][CH2:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577534295-(3,3,3-Trifluoro-propoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 866070105-(3,3,3-Trifluoro-propoxy)-2,3-dihydro-1H-isoindole trifluoroacetate

Procedure

Prepared in analogy to Example A2(c) from 5-(3,3,3-trifluoro-propoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown oil. MS (m/e): 232.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-d67e95534669472986129ad77b66807d
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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