Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 1,3-Isobenzofurandione, 5-fluoro- | HCID 67572 | — |
| Product | 5-Fluoroisoindoline-1,3-dione | HCID 10899038 | 100% |
Reaction Steps
A mixture of 144 mmol 4-fluorophthalic anhydride and 1.16 mol formamide was heated at 200° C. for 2 h. The reaction mixture was poured onto ice-water and the resulting crystals collected by filtration and dried in vacuo to afford the title compound as a yellow solid (100% yield). MS (m/e): 164.4 ([M−H]−, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08188139B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-d7bd131a8df94912b0d2a22b005f80f4 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
