Sodium Hydroxide → HCID 57753316, compound

HRID 1930965Notes

Reaction equation

HRID 1930965 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[C:7](=[O:14])[NH:6][C:5]2=[O:15].[Sn](Cl)Cl.[OH-].[Na+]>Cl>[NH2:11][C:10]1[CH:9]=[C:8]2[C:4](=[CH:3][C:2]=1[F:1])[C:5](=[O:15])[NH:6][C:7]2=[O:14]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 57753207HCID 57753207, compound

Product 1

HCID 57753316HCID 57753316, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
60 °C

Procedure

To a suspension of 99.9 mmol 5-fluoro-6-nitro-isoindole-1,3-dione in 400 ml concentrated hydrochloric acid was added 350 mmol tin(II) chloride dehydrate and the resulting mixture was heated at 60° C. for 2 h. The reaction mixture was then poured onto ice-water and then 28% aq sodium hydroxide was added with stirring until a suspension was formed. The crystals were collected by filtration and dried in vacuo to afford the title compound as a yellow solid (80% yield). MS (m/e): 179.1 ([M−H]−, 100%).

Workup

  1. additionThe reaction mixture was then poured onto ice-water
  2. customwas formed
  3. filtrationThe crystals were collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-73624b061f6b48f89f73808910940ae3
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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