Trifluoroacetic acid → HCID 68823671, compound

HRID 1930967Notes

Reaction equation

HRID 1930967 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[C:13]([F:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[F:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57753515HCID 57753515, compound

Product 1

HCID 68823671HCID 68823671, compound

Procedure

Prepared in analogy to Example A2(c) from 5-fluoro-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. MS (m/e): 223.4 (M+H]+, 100%).

Sources & evidence

ORD record
ord-1d3df0deff8c4803bbd4e4df9bc084fc
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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