Tetrahydro-4H-pyran-4-ol → HCID 57753506, compound

HRID 1930968Notes

Reaction equation

HRID 1930968 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12](I)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:19]1[CH2:24][CH2:23][CH:22]([OH:25])[CH2:21][CH2:20]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:25][CH:22]3[CH2:23][CH2:24][O:19][CH2:20][CH2:21]3)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 577534555-Chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic Acid Tert-Butyl Ester

Product 1

HCID 57753506HCID 57753506, compound

Procedure

Prepared in analogy to Example A6(a) from 5-chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A3(c)) and tetrahydro-4H-pyran-4-ol. Off-white solid. MS (m/e): 300.1 ([{37Cl}M+H-Me2C═CH2]+, 36%), 298.3 ([{35Cl}M+H-Me2C═CH2]+, 100%).

Sources & evidence

ORD record
ord-a32f2c4fd7bc44bd9b20d47bda187048
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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