Trifluoroacetic acid → HCID 68822550, compound

HRID 1930969Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:18][CH:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)[CH2:9][NH:8][CH2:16]2

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57753506HCID 57753506, compound

Product 1

HCID 68822550HCID 68822550, compound

Procedure

Prepared in analogy to Example A2(c) from 5-chloro-6-(tetrahydro-pyran-4-yloxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. 256.3 ([{37Cl}M+H]+, 50%), 254.3 ([{35Cl}M+H]+, 100%).

Sources & evidence

ORD record: ord-7d2f908b52a34aad9b3a0e9a6f66bdd2
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188139B2

Reaction notes

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