Trifluoroacetic acid → HCID 68826269, compound

HRID 1930971Notes

Reaction equation

HRID 1930971 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:13]([F:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[F:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:18][CH:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57753621HCID 57753621, compound

Product 1

HCID 68826269HCID 68826269, compound

Procedure

Prepared in analogy to Example A2(c) from 5-fluoro-6-(tetrahydro-pyran-4-yloxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. 238.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-b0e6109f87c046788cf474b98582fd0e
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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