Trifluoroacetic acid → 4-Iodoisoindoline

HRID 1931016Notes

Reaction equation

HRID 1931016 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][N:5](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:6]2.FC(F)(F)C(O)=O>>[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][NH:5][CH2:6]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577534134-Iodo-2-trityl-2,3-dihydro-1H-isoindole

Product 1

HCID 577536944-Iodoisoindoline

Procedure

Prepared in analogy to Example A2 (c) from 4-Iodo-2-trityl-2,3-dihydro-1H-isoindole and trifluoroacetic acid. Light yellow solid.

Sources & evidence

ORD record
ord-109e45dc0a1740bc8889cac91ea81cbb
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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