反应详情

温度

50 °C

To a mixture of 1-chloro-2-methylpropan-2-ol (2.2 g, 20.26 mmol) and potassium ethanethioate (6.94 g, 60.8 mmol) in DMF (20 mL) was added 100 mg of sodium bromide and the resulting mixture was heated at 50° C. for 18 hours. The mixture was then poured into water and extracted with EtOAc. The acetate layer was washed with water, brine, dried with MgSO4 and concentrated under reduced pressure to provide 3.4 g of the title compound.

1. extractionextracted with EtOAc
2. washThe acetate layer was washed with water, brine
3. dry with materialdried with MgSO4
4. concentrationconcentrated under reduced pressure