Water → HCID 68915096, compound

HRID 1931362Notes

Reaction equation

HRID 1931362 reaction equation
C[O:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][N:13](C)[C:14]([NH:16][CH:17]2[CH:24]3[CH2:25][CH:20]4[CH2:21][CH:22]([CH2:26][CH:18]2[CH2:19]4)[CH2:23]3)=[O:15])=[CH:6][CH:5]=1.[OH-].[Na+].O.[CH2:32]1COCC1>>[CH:18]12[CH2:26][CH:22]3[CH2:21][CH:20]([CH2:25][CH:24]([CH2:23]3)[CH:17]1[N:16]([CH3:32])[C:14](=[O:15])[NH:13][CH2:12][CH2:11][O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:2])=[O:28])=[CH:9][CH:8]=1)[CH2:19]2

Participants

5

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium Hydroxide2×HCID 23582290HCID 23582290, compound

Product 1

HCID 68915096HCID 68915096, compound

Procedure

A solution of 4-[2-(3-Adamantan-2-yl-1-methyl-ureido)-ethoxy]-benzoic acid methyl ester 562 mg (1.45 mmol), NaOH 1 N 3 ml in THF 5 ml was stirred at RT overnight. Then NaOH 1 N 4 ml was added and the reaction mixture stirred overnight. Water was added and the mixture acidified until pH=2.

Sources & evidence

ORD record
ord-549d92836380416d9057e7275afb90db
Source dataset
uspto-grants-2012_05
Patent number
US08188288B2

Reaction notes

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