反应详情

300 mg (1.26 mmol) of 3,6-dibromopyridazine, 176.5 mg (1.26 mmol) 2-fluoro-phenylboronic acid, 34.7 mg (0.038 mmol) of tetrakis(triphenylphosphine)palladium and 1.26 ml of an aqueous 1 M sodium carbonate solution in 15 ml of DME were heated under reflux for 3 h. After cooling, the reaction mixture was poured onto water and extracted with ethyl acetate. The combined organic phases were dried, evaporated, and the product purified by RP18 chromatography. Yield: 62 mg.

1. temperatureunder reflux for 3 h
2. temperatureAfter cooling
3. additionthe reaction mixture was poured onto water
4. extractionextracted with ethyl acetate
5. customThe combined organic phases were dried
6. customevaporated
7. customthe product purified by RP18 chromatography