HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-1-(piperidin-1-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | [6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid | HCID 68537815 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-1-(piperidin-1-yl)-ethanone | HCID 24946899 | — |
Reaction Steps
20 mg (0.08 mmol) of [6-(2-fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid, 10.3 mg (0.12 mmol) of piperidine, 27.8 mmol (0.24 mmol) of NEM and 29.1 mg (0.089 mmol) of TOTU in THF were stirred at room temperature for 3 h. After filtration and evaporation, the product was purified by RP18 chromatography. Yield: 7 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188291B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f0b40faf862749e9b40f9ca152ec209b |
| Source note | uspto-grants-2012_05 |