反应详情

To the crude (6-bromo-pyridazin-3-yloxy)-acetic acid tert-butyl ester obtained in step (a) 5 ml of 90% aqueous TFA were added, and the mixture was allowed to stand at room temperature for 3 h. After evaporation, a sodium hydrogencarbonate solution was added, and the solution extracted with ethyl acetate. The aqueous phase was acidified to pH=4 and extracted with ethyl acetate. The combined extracts were dried and evaporated. Yield: 147 mg.

1. customAfter evaporation
2. additiona sodium hydrogencarbonate solution was added
3. extractionthe solution extracted with ethyl acetate
4. extractionextracted with ethyl acetate
5. customThe combined extracts were dried
6. customevaporated