Hydrochloric Acid → HCID 68537793, compound

HRID 1931394Notes

Reaction equation

HRID 1931394 reaction equation
C[O:2][C:3](=[O:18])[CH2:4][CH2:5][C:6]1[S:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[CH:9][CH:10]=1.[OH-].[Na+].Cl>O1CCOCC1.O>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:8]1[S:7][C:6]([CH2:5][CH2:4][C:3]([OH:18])=[O:2])=[CH:10][CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68535097HCID 68535097, compound

Product 1

HCID 68537793HCID 68537793, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

500 mg (1.9 mmol) of 3-[5-(2-fluoro-phenyl)-thiophen-2-yl]-propionic acid methyl ester was dissolved in 5 ml of dioxane and 5 ml of a 2 N sodium hydroxide solution. The reaction mixture was stirred at room temperature for 16 h, diluted with water and acidified to pH=2 by the addition of concentrated hydrochloric acid. The precipitated product was isolated by filtration. Yield: 398 mg.

Workup

  1. customThe precipitated product was isolated by filtration

Sources & evidence

ORD record
ord-964e74e235f543b0b197828e3177fc13
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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