Trifluoroacetic acid → HCID 178525686, compound

HRID 1931396Notes

Reaction equation

HRID 1931396 reaction equation
C([O:5][C:6](=[O:20])[CH2:7][S:8][C:9]1[NH:10][CH:11]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[N:13]=1)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:12]2[N:13]=[C:9]([S:8][CH2:7][C:6]([OH:20])=[O:5])[NH:10][CH:11]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178451393HCID 178451393, compound

Product 1

HCID 178525686HCID 178525686, compound

Procedure

30 mg (0.1 mmol) of (4-(pyridin-3-yl)-1H-imidazol-2-ylsulfanyl)-acetic acid tert-butyl ester were allowed to stand in 1 ml of 90% aqueous TFA at room temperature for 1 h. The mixture was evaporated, and the product employed in the subsequent step without further purification. Yield: 33 mg.

Workup

  1. customThe mixture was evaporated
  2. customthe product employed in the subsequent step without further purification

Sources & evidence

ORD record
ord-4e540e74dcd04220be9771352cf03579
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

Loading…