HCID 68539930, compound → HCID 68539080, compound

HRID 1931406Notes

Reaction equation

HRID 1931406 reaction equation
C([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:11][N:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:12]1[CH:13]=[N:14][C:9]([O:8][CH2:7][C:6]([OH:22])=[O:5])=[N:10][CH:11]=1

Participants

3

Reactant 1

HCID 68539930HCID 68539930, compound

Product 1

HCID 68539080HCID 68539080, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

335 mg (1.1 mmol) of [5-(2-fluoro-phenyl)-pyrimidin-2-yloxy]-acetic acid tert-butyl ester in 10 ml of 90% aqueous TFA were allowed to stand at room temperature for 3 h. After evaporation, a sodium hydrogencarbonate solution was added, and the mixture was extracted with ethyl acetate. The aqueous phase was acidified to pH=4, extracted with ethyl acetate, and the combined organic phases were dried and evaporated. Yield: 51 mg.

Workup

  1. customAfter evaporation
  2. additiona sodium hydrogencarbonate solution was added
  3. extractionthe mixture was extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. customthe combined organic phases were dried
  6. customevaporated

Sources & evidence

ORD record
ord-5cfa0d71d49c4338ac4cc8ffacbf782e
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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