Pyrrolidine → HCID 59152277, compound

HRID 1931414Notes

Reaction equation

HRID 1931414 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68536712HCID 68536712, compound

Product 1

HCID 59152277HCID 59152277, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroacetic acid salt and 38.7 mg (0.54 mmol) of pyrrolidine. Yield: 6 mg.

Sources & evidence

ORD record
ord-6c62b7a19d584072bd639c96955f4e08
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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