2-Aminothiazole → HCID 59152246, compound

HRID 1931415Notes

Reaction equation

HRID 1931415 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH2:25][C:26]1[S:27][CH:28]=[CH:29][N:30]=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([NH:25][C:26]3[S:27][CH:28]=[CH:29][N:30]=3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 68536712HCID 68536712, compound

Product 1

HCID 59152246HCID 59152246, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 90 mg (0.24 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroacetic acid salt and 47 mg (0.47 mmol) of 2-amino-thiazole. Yield: 5 mg.

Sources & evidence

ORD record
ord-06c35e1e7cbb4212964b184ab6dfa885
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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