反应详情

温度

80 °C

Under nitrogen, 39.2 g (0.28 mol) of 2-fluoro-phenylboronic acid, 59.9 g (0.25 mol) of 2,5-dibromopyridine and 2.17 g of tetrakis(triphenylphosphine)palladium were dissolved in 420 ml of ethanol and 840 ml of toluene. 840 ml of a 2 N sodium carbonate solution were added, and the mixture heated to 80° C. for 1 h. Afterwards the mixture was cooled to 5 to 10° C., 800 ml of ethyl acetate were added, and the precipitated salts were separated by filtration. The organic phase of the mother liquor was separated, washed with a saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated to dryness.

1. temperatureAfterwards the mixture was cooled to 5 to 10° C.
2. customthe precipitated salts were separated by filtration
3. customThe organic phase of the mother liquor was separated
4. washwashed with a saturated sodium chloride solution
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated to dryness