HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n,n-dimethyl-acetamide trifluoroacetic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | [4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt | HCID 44184931 | — |
| Product | 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n,n-dimethyl-acetamide trifluoroacetic acid salt | HCID 86638130 | — |
Reaction Steps
The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt, 66.8 mg (0.81 mmol) of dimethylamine hydrochloride and 165.7 mg (1.64 mmol) of triethylamine. Yield: 52 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188291B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a1a050d4748541a9986e8bf3aa2d5360 |
| Source note | uspto-grants-2012_05 |