Triethylamine → 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n,n-dimethyl-acetamide trifluoroacetic acid salt

HRID 1931428Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.Cl.[CH3:26][NH:27][CH3:28].C(N(CC)CC)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([N:27]([CH3:28])[CH3:26])=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

Reactant 3

HCID 8471Triethylamine

HCID 10473Dimethylamine, hydrochloride

HCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 866381302-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-n,n-dimethyl-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt, 66.8 mg (0.81 mmol) of dimethylamine hydrochloride and 165.7 mg (1.64 mmol) of triethylamine. Yield: 52 mg.

Sources & evidence

ORD record: ord-a1a050d4748541a9986e8bf3aa2d5360
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

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