2-Aminothiazole → 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-N-thiazol-2-yl-acetamide trifluoroacetic acid salt

HRID 1931429Notes

Reaction equation

HRID 1931429 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH2:25][C:26]1[S:27][CH:28]=[CH:29][N:30]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([NH:25][C:26]3[S:27][CH:28]=[CH:29][N:30]=3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 866381312-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-N-thiazol-2-yl-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 200 mg (0.55 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 109.4 mg (1.1 mmol) of 2-aminothiazole. Yield: 3.3 mg.

Sources & evidence

ORD record
ord-40f8a3f327634396a7f3d91055bd1f2b
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

Loading…