2-(2-Fluorophenyl)-5-nitropyridine → 6-(2-Fluorophenyl)pyridin-3-amine

HRID 1931433Notes

Reaction equation

HRID 1931433 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1

Participants

4

Reactant 1

HCID 685377752-(2-Fluorophenyl)-5-nitropyridine

Product 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

50 mg of 10% palladium on carbon were added to a solution of 3.2 g (14.66 mmol) of 2-(2-fluoro-phenyl)-5-nitro-pyridine in 250 ml of ethanol, and the reaction mixture was hydrogenated at atmospheric pressure for 3 h. After filtration, the solution was evaporated. Yield: 2.5 g.

Workup

  1. filtrationAfter filtration
  2. customthe solution was evaporated

Sources & evidence

ORD record
ord-d19b76d01a564cf2a69b7f9ea02acc51
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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