6-(2-Fluorophenyl)pyridin-3-ol → 3-(4-Methyl-2-phenyl-pyrimidin-5-yl)-1-(piperidin-1-yl)-propan-1-one

HRID 1931441Notes

Reaction equation

HRID 1931441 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=O)=[CH:6][N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:3]=1.FC1C=CC=CC=1[C:26]1[N:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1>>[CH3:1][C:2]1[C:7]([CH2:8][CH2:9][C:10]([N:31]2[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]2)=[O:12])=[CH:6][N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 231457706-(2-Fluorophenyl)pyridin-3-olHCID 685380983-(4-Methyl-2-phenyl-pyrimidin-5-yl)-acrylic acid

Product 1

HCID 591522833-(4-Methyl-2-phenyl-pyrimidin-5-yl)-1-(piperidin-1-yl)-propan-1-one

Procedure

The title compound was prepared from 3-(4-methyl-2-phenyl-pyrimidin-5-yl)-acrylic acid analogously as described in Example 15(b) and (c).

Sources & evidence

ORD record
ord-0901bfec70ff4c82878450f2c1b4ccfb
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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