Trifluoroacetic acid → HCID 68539808, compound

HRID 1931444Notes

Reaction equation

HRID 1931444 reaction equation
C([O:5][C:6](=[O:22])[CH2:7][NH:8][C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>>[F:26][C:25]([F:28])([F:27])[C:23]([OH:29])=[O:24].[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[N:11]=[CH:10][C:9]([NH:8][CH2:7][C:6]([OH:22])=[O:5])=[CH:14][CH:13]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68536722HCID 68536722, compound

Product 1

HCID 68539808HCID 68539808, compound

Procedure

480 mg (1.59 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-ylamino]-acetic acid tert-butyl ester in 5 ml of 90% aqueous TFA were allowed to stand at room temperature overnight. The mixture was concentrated and lyophilized. Yield: 587 mg.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-1870e2e4f9944719abaffade191050e8
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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