Pyrrolidine → HCID 68539764, compound

HRID 1931446Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[O:25])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 68539808HCID 68539808, compound

Product 1

HCID 68539764HCID 68539764, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 98 mg (0.27 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-ylamino]-acetic acid trifluoroacetic acid salt and 38.7 mg (0.54 mmol) pyrrolidine. Yield: 4 mg.

Sources & evidence

ORD record: ord-a0809de5ba634c69bbf61a3b87abab04
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

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