Piperidine → HCID 68537973, compound

HRID 1931449Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=1.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[O:25])=[CH:17][CH:16]=1

Participants

Reactant 2

HCID 8082Piperidine

HCID 68539088HCID 68539088, compound

Product 1

HCID 68537973HCID 68537973, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 79 mg (0.21 mmol) of [6-(2-fluoro-phenyl)-pyridin-3-ylamino]-acetic acid trifluoroacetic acid salt and 35.7 mg (0.42 mmol) piperidine. Yield: 4.3 mg.

Sources & evidence

ORD record: ord-b358baab92d645e2affcae5cfe1cade7
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

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