HCID 68537906, compound → N-(5-Phenyl-1,3,4-thiadiazol-2-yl)glycine

HRID 1931451Notes

Reaction equation

HRID 1931451 reaction equation
C([O:5][C:6](=[O:20])[CH2:7][NH:8][C:9]1[S:10][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:12][N:13]=1)(C)(C)C>C(O)(C(F)(F)F)=O.ClCCl>[C:14]1([C:11]2[S:10][C:9]([NH:8][CH2:7][C:6]([OH:20])=[O:5])=[N:13][N:12]=2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 1

HCID 68537906HCID 68537906, compound

Product 1

HCID 68538117N-(5-Phenyl-1,3,4-thiadiazol-2-yl)glycine

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

290 mg (0.99 mmol) of (5-phenyl-[1,3,4]thiadiazol-2-ylamino)-acetic acid tert-butyl ester in 5 ml of TFA and 5 ml of dichloromethane at room temperature for 16 h. The volatiles were removed under reduced pressure.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-8ad03fd5f43a4a7496f03b8d72b07384
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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