Trifluoroacetic acid → HCID 68538926, compound

HRID 1931453Notes

Reaction equation

HRID 1931453 reaction equation
C([O:5][C:6](=[O:21])[CH2:7][S:8][C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:13]=1)(C)(C)C.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[N:13]=[C:9]([S:8][CH2:7][C:6]([OH:21])=[O:5])[S:10][CH:11]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68537730HCID 68537730, compound

Product 1

HCID 68538926HCID 68538926, compound

Procedure

709 mg (2.07 mmol) of [4-(4-chloro-phenyl)-thiazol-2-ylsulfanyl]-acetic acid tert-butyl ester in 5 ml of 90% aqueous TFA were allowed to stand at room temperature for 5 h. The mixture was evaporated. Yield: 665 mg.

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-8d6b299616e64936939f261feba5806b
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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