Pyrrolidine → HCID 3691073, compound

HRID 1931454Notes

Reaction equation

HRID 1931454 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([S:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([S:20][CH2:21][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68538926HCID 68538926, compound

Product 1

HCID 3691073HCID 3691073, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.25 mmol) of [4-(4-chloro-phenyl)-thiazol-2-ylsulfanyl]-acetic acid trifluoroacetic acid salt and 35.6 mg (0.5 mmol) of pyrrolidine. Yield: 51 mg.

Sources & evidence

ORD record
ord-a685920a86fd4cbba186c139a4a8ec17
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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